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Article

Non-image-forming light driven functions are preserved in a mouse model of autosomal dominant optic atrophy.

PloS one - 1 Jan 2013

Perganta Georgia, Barnard Alun R, Katti Christiana, Vachtsevanos Athanasios, Douglas Ron H, MacLaren Robert E, Votruba Marcela, Sekaran Sumathi

Abstract excerpt

Autosomal dominant optic atrophy (ADOA) is a slowly progressive optic neuropathy that has been associated with mutations of the OPA1 gene. In patients, the disease primarily affects the retinal ganglion cells (RGCs) and causes optic nerve atrophy and visual loss. A subset of RGCs are intrinsically photosensitive, express the photopigment melanopsin and drive non-image-forming (NIF) visual functions including...

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Source

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Identifiers

PMID: 23409176
DOI: 10.1371/journal.pone.0056350
PMCID: PMC3569441

Genes

OPA1

Provenance

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