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Article

ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis.

The Journal of biological chemistry - 14 Mar 2003

Koch Thomas, Brandenburg Lars-Ove, Schulz Stefan, Liang Yingjian, Klein Jochen, Hollt Volker

Abstract excerpt

Agonist exposure of many G protein-coupled receptors induces a rapid receptor phosphorylation and uncoupling from G proteins. Resensitization of these desensitized receptors requires endocytosis and subsequent dephosphorylation. Using a yeast two-hybrid screen, the rat mu-opioid receptor (MOR1, also termed MOP) was found to be associated with phospholipase D2 (PLD2), a phospholipid-specific phosphodiesterase...

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Source

Identifiers

PMID: 12519790
DOI: 10.1074/jbc.M206709200

Genes

PLD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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