Magnetic resonance angiography-defined intracranial vasculopathy is associated with silent cerebral infarcts and glucose-6-phosphate dehydrogenase mutation in children with sickle cell anaemia.

doi:10.1111/bjh.12034

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Article

Magnetic resonance angiography-defined intracranial vasculopathy is associated with silent cerebral infarcts and glucose-6-phosphate dehydrogenase mutation in children with sickle cell anaemia.

British journal of haematology - 1 Nov 2012

Thangarajh Mathula, Yang Genyan, Fuchs Dana, Ponisio Maria R, McKinstry Robert C, Jaju Alok, Noetzel Michael J, Casella James F, Barron-Casella Emily, Hooper W Craig, Boulet Sheree L, Bean Christopher J, Pyle Meredith E, Payne Amanda B, Driggers Jennifer, Trau Heidi A, Vendt Bruce A, Rodeghier Mark, DeBaun Michael R

Abstract excerpt

Silent cerebral infarct (SCI) is the most commonly recognized cause of neurological injury in sickle cell anaemia (SCA). We tested the hypothesis that magnetic resonance angiography (MRA)-defined vasculopathy is associated with SCI. Furthermore, we examined genetic variations in glucose-6-phosphate dehydrogenase (G6PD) and HBA (α-globin) genes to determine their association with intracranial vasculopathy in...

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PMID: 22958163
DOI: 10.1111/bjh.12034
PMCID: PMC3775590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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