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Article

Genetic modulation of tau phosphorylation in the mouse.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jan 2003

Brich Jochen, Shie Feng-Shiun, Howell Brian W, Li Renhua, Tus Katalin, Wakeland Edward K, Jin Lee-Way, Mumby Marc, Churchill Gary, Herz Joachim, Cooper Jonathan A

Abstract excerpt

The axonal microtubule stabilizing protein tau is hyperphosphorylated in several neurodegenerative conditions, including Alzheimer's disease, yet the genes that regulate tau phosphorylation are largely unknown. Disabled-1 (Dab1) is a cytoplasmic adapter protein that interacts with apolipoprotein E (ApoE) receptors and controls neuronal positioning during embryonic brain development. We have investigated the role...

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Identifiers

PMID: 12514215
PMCID: PMC6742161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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