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Article

Mapping genetic modulators of amyloid plaque deposition in TgCRND8 transgenic mice.

Human molecular genetics - 1 Aug 2006

Sebastiani Giovanna, Krzywkowski Pascale, Dudal Sherri, Yu Mathilde, Paquette Julie, Malo Danielle, Gervais Francine, Tremblay Patrick

Abstract excerpt

Alzheimer's disease (AD) is a complex disorder for which various in vivo models exist. The TgCRND8 mouse, transgenic for the human amyloid precursor protein, is an aggressive early onset model of brain amyloid deposition. Preliminary studies revealed that when the transgene is expressed on an A/J genetic background, these mice not only survive longer but also deposit less parenchymal amyloid-beta (Abeta) peptides...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16785251
DOI: 10.1093/hmg/ddl157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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