Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generation of a New Tau Knockout (tau Δex1 ) Line Using CRISPR/Cas9 Genome Editing in Mice

20 Feb 2018

Abstract excerpt

Alzheimer's disease and other dementias present with tau pathology. Several mouse lines with knockout of the tau-encoding Mapt gene have been reported, yet findings often differed between lines and sites. Here, we report a new tau knockout strain (tauΔex1), generated by CRISPR/Cas9-mediated genome editing of intron -1/exon 1 of Mapt in C57Bl/6J mice. TauΔex1 mice had no overt phenotype, but, in line with previous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Medicinal Plants and Neuroprotection
Share to Neuroscience and Neuropharmacology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29480201
DOI: 10.3233/jad-171058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generation of a New Tau Knockout (tau Δex1 ) Line Using CRISPR/Cas9 Genome Editing in MicePMID 29480201Read ↗

The TAU isoform 1N4R restores vulnerability of MAPT knockout human iPSC-derived neurons to Amyloid beta-induced neuronal dysfunctionSemantic proximity Read ↗

Lessons from Tau-Deficient MiceSemantic proximity Read ↗

MAPT mutations, tauopathy, and mechanisms of neurodegenerationSemantic proximity Read ↗

CRISPR base editing-mediated correction of a tau mutation rescues cognitive decline in a mouse model of tauopathySemantic proximity Read ↗

Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSPSemantic proximity Read ↗

No Overt Deficits in Aged Tau-Deficient C57Bl/6.Mapttm1(EGFP)Kit GFP Knockin MiceSemantic proximity Read ↗

Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse ModelSemantic proximity Read ↗

Single <i>MAPT</i> knock-in mouse models of frontotemporal dementia for sharing with the neurodegenerative research communitySemantic proximity Read ↗

Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration.Semantic proximity Read ↗

Promoter mutagenesis and a massively parallel reporter screen of the <i>MAPT</i> locus identifies cis-regulatory elements and genetic variation effectsSemantic proximity Read ↗

Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau PathologySemantic proximity Read ↗

New insights into genetic and molecular mechanisms of brain degeneration in tauopathiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.