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Article

Genetic loci contributing to age-related hippocampal lesions in mice.

Neurobiology of disease - 1 Jul 2003

Krass Kelly L, Colinayo Veronica, Ghazalpour Anatole, Vinters Harry V, Lusis Aldons J, Drake Thomas A

Abstract excerpt

C57BL/6J mice develop genetically determined age-related hippocampal granular deposits that have some similarities to lesions seen in the brains of human patients with tau protein related neurodegenerative disorders ("tauopathies"). We sought to identify the genetic loci responsible for these in an F2 intercross of inbred mouse strains C57BL/6J and DBA/2J, using quantitative trait locus (QTL) analysis....

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PMID: 12828934
DOI: 10.1016/s0969-9961(03)00034-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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