Article
The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease.
Gastroenterology - 1 Apr 2002
Cuthbert Andrew P, Fisher Sheila A, Mirza Muddassar M, King Kathy, Hampe Jochen, Croucher Peter J P, Mascheretti Silvia, Sanderson Jeremy, Forbes Alastair, Mansfield John, Schreiber Stefan, Lewis Cathryn M, Mathew Christopher G
Abstract excerpt
BACKGROUND & AIMS: Mutations in the NOD2 gene are strongly associated with susceptibility to Crohn's disease (CD). We analyzed a large cohort of European patients with inflammatory bowel disease to determine which mutations confer susceptibility, the degree of risk conferred, their prevalence in familial and sporadic forms of the disease, and whether they are associated with site of disease. METHODS: Individuals...
Topics
- Carrier Proteins
- Cohort Studies
- Colon
- Crohn Disease
- Family Health
- Female
- Frameshift Mutation
- Genetic Linkage
- Genetic Predisposition to Disease
- Humans