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Article

Role of duplicate genes in genetic robustness against null mutations.

Nature - 2 Jan 2003

Gu Zhenglong, Steinmetz Lars M, Gu Xun, Scharfe Curt, Davis Ronald W, Li Wen-Hsiung

Abstract excerpt

Deleting a gene in an organism often has little phenotypic effect, owing to two mechanisms of compensation. The first is the existence of duplicate genes: that is, the loss of function in one copy can be compensated by the other copy or copies. The second mechanism of compensation stems from alternative metabolic pathways, regulatory networks, and so on. The relative importance of the two mechanisms has not been...

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PMID: 12511954
DOI: 10.1038/nature01198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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