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Article

Genetic interactions reveal the evolutionary trajectories of duplicate genes.

Molecular systems biology - 16 Nov 2010

VanderSluis Benjamin, Bellay Jeremy, Musso Gabriel, Costanzo Michael, Papp Balázs, Vizeacoumar Franco J, Baryshnikova Anastasia, Andrews Brenda, Boone Charles, Myers Chad L

Abstract excerpt

The characterization of functional redundancy and divergence between duplicate genes is an important step in understanding the evolution of genetic systems. Large-scale genetic network analysis in Saccharomyces cerevisiae provides a powerful perspective for addressing these questions through quantitative measurements of genetic interactions between pairs of duplicated genes, and more generally, through the study...

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Identifiers

PMID: 21081923
DOI: 10.1038/msb.2010.82
PMCID: PMC3010121

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