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Article

Mechanisms underlying PTEN regulation of vascular endothelial growth factor and angiogenesis

31 Dec 2002

Abstract excerpt

Inactivation of the tumor suppressor gene PTEN and overexpression of VEGF are two of the most common events observed in high-grade malignant gliomas. The purpose of this study was to determine whether PTEN controls VEGF expression in gliomas under normoxic conditions. Transfer of PTEN to human glioma cells resulted in the transduction of a functional PTEN protein as evidenced by the upregulation of p27 and...

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PMID: 12509854
DOI: 10.1002/ana.10396

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