Article
PTEN controls tumor-induced angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 10 Apr 2001
Wen S, Stolarov J, Myers M P, Su J D, Wigler M H, Tonks N K, Durden D L
Abstract excerpt
Mutations of the tumor suppressor PTEN, a phosphatase with specificity for 3-phosphorylated inositol phospholipids, accompany progression of brain tumors from benign to the most malignant forms. Tumor progression, particularly in aggressive and malignant tumors, is associated with the induction of angiogenesis, a process termed the angiogenic switch. Therefore, we tested whether PTEN regulates tumor progression...
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