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Article

Protein phosphatase activity of PTEN inhibited the invasion of glioma cells with epidermal growth factor receptor mutation type III expression.

International journal of cancer - 20 Dec 2005

Cai Xiu-Mei, Tao Bei-Bei, Wang Li-Ying, Liang Yu-Long, Jin Jia-Wei, Yang Yong, Hu Ya-Li, Zha Xi-Liang

Abstract excerpt

PTEN is a major tumor suppressor gene that has been shown to inhibit cell invasion. Its mutation has been found in 20-40% of malignant gliomas. Meanwhile, the type III EGFR mutation (EGFRvIII), which was frequently found in gliomas, promoted cell invasion. In the present study, the effects of PTEN on cell invasion were investigated in U87DeltaEGFR glioblastoma cells with EGFRvIII expression but missing PTEN. The...

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Source

Identifiers

PMID: 15986432
DOI: 10.1002/ijc.21251

Genes

PTEN
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Protein phosphatase activity of PTEN inhibited the invasion of glioma cells with epidermal growth factor receptor mutation type III expression.PMID 15986432Read ↗

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