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Article

Two ZBP1 KH domains facilitate beta-actin mRNA localization, granule formation, and cytoskeletal attachment.

The Journal of cell biology - 6 Jan 2003

Farina Kim L, Huttelmaier Stefan, Musunuru Kiran, Darnell Robert, Singer Robert H

Abstract excerpt

Chicken embryo fibroblasts (CEFs) localize beta-actin mRNA to their lamellae, a process important for the maintenance of cell polarity and motility. The localization of beta-actin mRNA requires a cis localization element (zipcode) and involves zipcode binding protein 1 (ZBP1), a protein that specifically binds to the zipcode. Both localize to the lamellipodia of polarized CEFs. ZBP1 and its homologues contain two...

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Identifiers

PMID: 12507992
DOI: 10.1083/jcb.200206003
PMCID: PMC2172732

Genes

ZBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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