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Article

Sonic Hedgehog Guides Axons via Zipcode Binding Protein 1-Mediated Local Translation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Feb 2017

Lepelletier Léa, Langlois Sébastien D, Kent Christopher B, Welshhans Kristy, Morin Steves, Bassell Gary J, Yam Patricia T, Charron Frédéric

Abstract excerpt

Sonic hedgehog (Shh) attracts spinal cord commissural axons toward the floorplate. How Shh elicits changes in the growth cone cytoskeleton that drive growth cone turning is unknown. We find that the turning of rat commissural axons up a Shh gradient requires protein synthesis. In particular, Shh stimulation increases β-actin protein at the growth cone even when the cell bodies have been removed. Therefore, Shh...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28073938
DOI: 10.1523/JNEUROSCI.3016-16.2016
PMCID: PMC6589976

Genes

ZBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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