Article
ZBP1 subcellular localization and association with stress granules is controlled by its Z-DNA binding domains.
Nucleic acids research - 1 Jan 2006
Deigendesch Nikolaus, Koch-Nolte Friedrich, Rothenburg Stefan
Abstract excerpt
Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Zalpha domain, which binds specifically to left-handed Z-DNA and Z-RNA. Like all vertebrate proteins in the Zalpha family, it contains two Zalpha-like domains and is highly inducible by immunostimulation. Using circular dichroism spectroscopy and electrophoretic mobility shift assays we show that both Zalpha domains can bind Z-DNA...
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