Article
In vitro studies of Flemish, Dutch, and wild-type beta-amyloid provide evidence for two-staged neurotoxicity.
Neurobiology of disease - 1 Nov 2002
Kumar-Singh Samir, Julliams Ann, Nuydens Rony, Ceuterick Chantal, Labeur Christine, Serneels Sally, Vennekens Krist'l, Van Osta Peter, Geerts Hugo, De Strooper Bart, Van Broeckhoven Christine
Abstract excerpt
Mutations in the beta-amyloid (Abeta) sequence of the amyloid precursor protein gene (APP) present with variable disease phenotypes. While patients with the Dutch APP mutation (E693Q) have predominantly hemorrhagic strokes, Flemish APP (A692G) patients develop both strokes and Alzheimer's disease (AD). To determine whether these diverse clinical and pathological presentations are due to mutant Abeta or APP, we...
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