Article
β-Amyloid carrying the Dutch mutation has diverse effects on calpain-mediated toxicity in hippocampal neurons.
Molecular medicine (Cambridge, Mass.) - 27 Mar 2012
Nicholson Alexandra M, Wold Lindsey A, Walsh Dominic M, Ferreira Adriana
Abstract excerpt
Hereditary cerebral hemorrhage with amyloidosis-Dutch type is a disorder associated with a missense mutation (E693Q) in the β-amyloid (Aβ)-coding region of the amyloid precursor protein (APP). This familial disease is characterized by cognitive deficits secondary to intracerebral hemorrhage and, in some cases, progressive Alzheimer's disease (AD)-like dementia. Although this mutation was the first ever reported...
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