Article
Promoter polymorphisms -359T/C and -303A/G of the catalytic subunit p110beta gene of human phosphatidylinositol 3-kinase are not associated with insulin secretion or insulin sensitivity in finnish subjects.
Diabetes care - 1 Jan 2003
Kossila Maija, Pihlajamäki Jussi, Kärkkäinen Päivi, Miettinen Raija, Kekäläinen Päivi, Vauhkonen Ilkka, Ylä-Herttuala Seppo, Laakso Markku
Abstract excerpt
OBJECTIVE: Phosphatidylinositol (PI) 3-kinase activity is required for insulin-stimulated translocation of GLUT4 transporters and glucose uptake and utilization. Therefore, genes encoding the subunits of PI 3-kinase are promising candidate genes for insulin resistance and type 2 diabetes. We recently cloned the catalytic subunit p110beta gene of human PI 3-kinase and reported two nucleotide polymorphisms, -359T/C...
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