Article
A new variant in the human Kv1.3 gene is associated with low insulin sensitivity and impaired glucose tolerance.
The Journal of clinical endocrinology and metabolism - 1 Feb 2006
Tschritter Otto, Machicao Fausto, Stefan Norbert, Schäfer Silke, Weigert Cora, Staiger Harald, Spieth Christian, Häring Hans-Ulrich, Fritsche Andreas
Abstract excerpt
CONTEXT: The voltage-gated potassium channel Kv1.3 (KCNA3) is expressed in a variety of tissues including liver and skeletal muscle. In animal models, knockout of Kv1.3 has been found to improve insulin sensitivity and glucose tolerance. OBJECTIVE: We examined whether mutations in the Kv1.3 gene exist in humans and whether they are associated with alterations of glucose homeostasis. DESIGN AND SETTING: We...
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