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Article

Glucokinase gene islet promoter region variant (G-->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns.

Diabetes care - 1 Jul 1998

Rissanen J, Saarinen L, Heikkinen S, Kekäläinen P, Mykkänen L, Kuusisto J, Deeb S S, Laakso M

Abstract excerpt

OBJECTIVE: To investigate the effect of the islet promoter region variant (G-->A) at nucleotide -30 of the glucokinase (GCK) gene on insulin levels in subjects with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and NIDDM. RESEARCH DESIGN AND METHODS: The study population included 294 subjects with NGT, 83 subjects with IGT, and 36 subjects with NIDDM. Oral glucose tolerance tests (OGTTs) were...

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Source

Identifiers

PMID: 9653619
DOI: 10.2337/diacare.21.7.1194

Genes

GCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glucokinase gene islet promoter region variant (G-->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns.PMID 9653619Read ↗

Glucokinase gene variants in subjects with late-onset NIDDM and impaired glucose tolerance.Semantic proximity Read ↗

A variation at position -30 of the beta-cell glucokinase gene promoter is associated with reduced beta-cell function in middle-aged Japanese-American men.Semantic proximity Read ↗

The beta cell glucokinase promoter variant is an unlikely risk factor for diabetes mellitus. Diabetes Incidence Study in Sweden (DISS).Semantic proximity Read ↗

Glucokinase gene variations in Japanese-Americans with a family history of NIDDM.Semantic proximity Read ↗

Promoter polymorphisms -359T/C and -303A/G of the catalytic subunit p110beta gene of human phosphatidylinositol 3-kinase are not associated with insulin secretion or insulin sensitivity in finnish subjects.Semantic proximity Read ↗

Glucokinase gene in gestational diabetes mellitus: population association study and molecular scanning.Semantic proximity Read ↗

Studies of the impact of a liver glucokinase promoter variant on glucose tolerance and insulin sensitivity index.Semantic proximity Read ↗

Homozygosity for a common polymorphism in the islet-specific promoter of the glucokinase gene is associated with a reduced early insulin response to oral glucose in pregnant women.Semantic proximity Read ↗

Glucokinase, the pancreatic glucose sensor, is not the gut glucose sensor.Semantic proximity Read ↗

A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites.Semantic proximity Read ↗

Analysis of the glucokinase gene promoter in Japanese subjects with noninsulin-dependent diabetes mellitus.Semantic proximity Read ↗

The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes.Semantic proximity Read ↗

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