Article
Chronic graft dysfunction in renal transplant patients: potential role of plasminogen activator inhibitor type 1.
Transplantation - 27 Apr 2002
Lahlou Anis, Peraldi Marie-Noëlle, Thervet Eric, Flahault Antoine, Delarue Françoise, Soubrier Florent, Rossert Jérôme, Hertig Alexandre, Rondeau Eric
Abstract excerpt
BACKGROUND: Chronic allograft nephropathy is the main cause of long-term kidney graft loss. The plasminogen activator inhibitor type 1 (PAI-1) is a potential fibrogenic molecule whose secretion is regulated by several metabolic, inflammatory, and genetic factors. We aimed to determine whether PAI-1 secretion in renal transplant patients is correlated with the decline in renal function after transplantation....
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