Article
Targeted cloning of cytotoxic T cells specific for minor histocompatibility antigens restricted by HLA class I molecules of interest.
Transplantation - 27 Dec 2002
Akatsuka Yoshiki, Kondo Eisei, Taji Hirohumi, Morishima Yasuo, Yazaki Makoto, Obata Yuichi, Kodera Yoshihisa, Riddell Stanley R, Takahashi Toshitada
Abstract excerpt
BACKGROUND: T cells specific for minor histocompatibility antigens (mHAgs) play a major role in both graft-versus-host disease and the graft-versus-tumor effect after HLA-identical bone marrow transplantation (BMT). However, characterization of individual T-cell responses to mHAgs is difficult and has generally involved extensive screening of T-cell clones isolated from bulk T-cell cultures generated from BMT...
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