Article
Identification of MHC II-restricted minor histocompatibility antigens after HLA-identical stem-cell transplantation.
Transplantation - 15 Nov 2010
Milosevic Slavoljub, Bachnick Barbara, Karim Karzan, Bornkamm Georg W, Witter Klaus, Gerbitz Armin, Mautner Josef, Behrends Uta
Abstract excerpt
BACKGROUND: After allogeneic hematopoietic stem-cell transplantation (HSCT), donor-derived T cells may elicit graft-versus-host disease (GVHD) and graft-versus-tumor (GVT) responses. The main targets of GVHD and GVT responses after human leukocyte antigen (HLA)-identical HSCT are minor histocompatibility antigens (mHAgs), that is, polymorphic gene products in which recipient and donor differ. Thus, for increasing...
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