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Article

Selection of CMV-specific CD8+ and CD4+ T cells by mini-EBV-transformed B cell lines

22 Jun 2005

Abstract excerpt

Efficient protocols to generate cytomegalovirus (CMV)-specific T cells are required for adoptive immunotherapy. Recombinant Epstein-Barr virus (EBV) vectors called mini-EBV can be used to establish permanent B cell lines in a single step, which present the CMV antigen pp65 in a constitutive manner. These B cell lines, coined pp65 mini-LCL, were successfully used to reactivate and expand CMV-specific cytotoxic T...

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PMID: 15971271
DOI: 10.1002/eji.200425936

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