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Article

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis.

The Journal of cell biology - 23 Dec 2002

Karbowski Mariusz, Lee Yang-Ja, Gaume Brigitte, Jeong Seon-Yong, Frank Stephan, Nechushtan Amotz, Santel Ansgar, Fuller Margaret, Smith Carolyn L, Youle Richard J

Abstract excerpt

We find that Bax, a proapoptotic member of the Bcl-2 family, translocates to discrete foci on mitochondria during the initial stages of apoptosis, which subsequently become mitochondrial scission sites. A dominant negative mutant of Drp1, Drp1K38A, inhibits apoptotic scission of mitochondria, but does not inhibit Bax translocation or coalescence into foci. However, Drp1K38A causes the accumulation of...

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Identifiers

PMID: 12499352
DOI: 10.1083/jcb.200209124
PMCID: PMC2173996

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