Article
Mitochondrial disruption in Drosophila apoptosis.
Developmental cell - 1 May 2007
Abdelwahid Eltyeb, Yokokura Takakazu, Krieser Ronald J, Balasundaram Sujatha, Fowle William H, White Kristin
Abstract excerpt
Mitochondrial disruption is a conserved aspect of apoptosis, seen in many species from mammals to nematodes. Despite significant conservation of other elements of the apoptotic pathway in Drosophila, a broad role for mitochondrial changes in apoptosis in flies remains unconfirmed. Here, we show that Drosophila mitochondria become permeable in response to the expression of Reaper and Hid, endogenous regulators of...
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