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Article

hFis1, a novel component of the mammalian mitochondrial fission machinery.

The Journal of biological chemistry - 19 Sept 2003

James Dominic I, Parone Philippe A, Mattenberger Yves, Martinou Jean-Claude

Abstract excerpt

The balance between the fission and fusion mechanisms regulate the morphology of mitochondria. In this study we have identified a mammalian protein that we call hFis1, which is the orthologue of the yeast Fis1p known to participate in yeast mitochondrial division. hFis1, when overexpressed in various cell types, localized to the outer mitochondrial membrane and induced mitochondrial fission. This event was...

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Identifiers

PMID: 12783892
DOI: 10.1074/jbc.M303758200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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