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Article

The role of the zebrafish nodal-related genes squint and cyclops in patterning of mesendoderm.

Development (Cambridge, England) - 1 May 2003

Dougan Scott T, Warga Rachel M, Kane Donald A, Schier Alexander F, Talbot William S

Abstract excerpt

Nodal signals, a subclass of the TGFbeta superfamily of secreted factors, induce formation of mesoderm and endoderm in vertebrate embryos. We have examined the possible dorsoventral and animal-vegetal patterning roles for Nodal signals by using mutations in two zebrafish nodal-related genes, squint and cyclops, to manipulate genetically the levels and timing of Nodal activity. squint mutants lack dorsal...

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Identifiers

PMID: 12642489
DOI: 10.1242/dev.00400

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

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The role of the zebrafish nodal-related genes squint and cyclops in patterning of mesendoderm.PMID 12642489Read ↗

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Lefty proteins are long-range inhibitors of squint-mediated nodal signaling.Semantic proximity Read ↗

Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling.Semantic proximity Read ↗

Environmental and genetic modifiers of squint penetrance during zebrafish embryogenesis.Semantic proximity Read ↗

Nodal-dependent mesendoderm specification requires the combinatorial activities of FoxH1 and Eomesodermin.Semantic proximity Read ↗

Goosecoid expression in neurectoderm and mesendoderm is disrupted in zebrafish cyclops gastrulas.Semantic proximity Read ↗

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