Article
CD14 and TNfa promoter polymorphisms in patients with acute arthritis. Special reference to development of chronic spondyloarthropathy.
Scandinavian journal of rheumatology - 1 Jan 2002
Repo Heikki, Anttonen Krista, Kilpinen Sami K, Palotie Aarno, Salven Petri, Orpana Arto, Leirisalo-Repo Marjatta
Abstract excerpt
OBJECTIVE: To examine CD14 and TNFalpha gene polymorphisms in early arthritis in relation to clinical outcome. METHODS: We studied 141 Caucasians who had had early arthritis 10 to 38 years earlier. We analysed CD14 (-159) and TNFalpha (-238, -308, -376) polymorphisms using a novel cycle minisequencing method. DNA pools from 370 Caucasian blood donors served as controls. RESULTS: CD14 (-159)C-->T allele...
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