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Article

CD14 promoter polymorphism -159C>T is associated with susceptibility to chronic Chlamydia pneumoniae infection in peripheral blood monocytes.

Genes and immunity - 1 Aug 2004

Rupp J, Goepel W, Kramme E, Jahn J, Solbach W, Maass M

Abstract excerpt

Chlamydia pneumoniae uses peripheral blood monocytes (PBMC) for systemic dissemination and has been linked to atherogenesis by inflammation mediated via TLR2/4 and CD14. We found 12.8% of 610 coronary artery disease (CAD) patients of Central European background to be chronically infected with C. pneumoniae based on the repeated detection of chlamydial DNA in PBMC. Among those the -159C>T CD14 promoter...

Read the complete abstract on PubMed

Topics

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Share to Antibodies, Bacterial
Share to Chlamydia Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chlamydophila pneumoniae

Share to Gene Frequency

Share to Lipopolysaccharide Receptors

Share to Monocytes

Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 15175649
DOI: 10.1038/sj.gene.6364112

Genes

CAD
TLR2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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