Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[The mechanism of A beta production and its inhibition as a therapeutic strategy for the prevention of Alzheimer's disease].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica - 1 Nov 2002

Iwatsubo Takeshi

Abstract excerpt

Deposition of amyloid beta peptide (A beta) as senile plaques or cerebrovascular amyloid characterizes the brains of patients with Alzheimer's disease (AD). A beta are composed of 40-42 amino acids that are proteolytically produced from its precursor beta APP. We have shown that the deposition of A beta ending at the 42nd residue (A beta 42) is one of the earliest pathological changes in AD brains. Genetic and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Amyloid Precursor Protein Secretases

Share to Aspartic Acid Endopeptidases

Share to Endopeptidases

Share to Enzyme Inhibitors

Share to Presenilin-1

Share to Presenilin-2

Source

Identifiers

PMID: 12491772

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[The mechanism of A beta production and its inhibition as a therapeutic strategy for the prevention of Alzheimer's disease].PMID 12491772Read ↗

[Beta-amyloid protein: recent progress in basic research and therapeutic approaches].Semantic proximity Read ↗

[beta-amyloid cascade: current status and future directions].Semantic proximity Read ↗

[Alzheimer's disease: basic aspects].Semantic proximity Read ↗

[Recent advances in Alzheimer's disease research--amyloid precursor protein trafficking, processing, and mutations in Alzheimer's disease linked genes].Semantic proximity Read ↗

Closing in on the amyloid cascade: recent insights into the cell biology of Alzheimer's disease.Semantic proximity Read ↗

[Alzheimer's disease: a molecular mechanism, new hypotheses, and therapeutic strategies].Semantic proximity Read ↗

Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.Semantic proximity Read ↗

Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease.Semantic proximity Read ↗

APP, Notch, and presenilin: molecular pieces in the puzzle of Alzheimer's disease.Semantic proximity Read ↗

Pathogenic Aβ generation in familial Alzheimer's disease: novel mechanistic insights and therapeutic implications.Semantic proximity Read ↗

[Molecular basics of Alzheimer's disease].Semantic proximity Read ↗

The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.