Article
The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught?
Pharmacological research - 1 Oct 2004
Verdile Giuseppe, Fuller Stephanie, Atwood Craig S, Laws Simon M, Gandy Samuel E, Martins Ralph N
Abstract excerpt
The beta amyloid (A beta) protein is a key molecule in the pathogenesis of Alzheimer's disease (AD). The tendency of the A beta peptide to aggregate, its reported neurotoxicity, and genetic linkage studies, have led to a hypothesis of AD pathogenesis that many AD researchers term the amyloid cascade hypothesis. In this hypothesis, an increased production of A beta results in neurodegeneration and ultimately...
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