Article
[Recent advances in Alzheimer's disease research--amyloid precursor protein trafficking, processing, and mutations in Alzheimer's disease linked genes].
[Hokkaido igaku zasshi] The Hokkaido journal of medical science - 1 Jan 1997
Fukatsu R, Tsuzuki K, Hayashi Y, Takamaru Y, Sasaki N, Yoshida T, Hatakeyama Y, Fuji N, Takahata N
Abstract excerpt
Recent advances in Alzheimer's disease (AD) research were briefly reviewed. The AD affected brain is characterized by numerous amyloid plaques, neurofibrillary tangles, and neuronal losses. The amyloid is composed of amyloid beta peptide (A beta), a 40-42 amino acid fragment of large membrane protein, amyloid precursor protein (APP). A beta is cleaved by proteolytic enzyme, beta, and gamma secretase yielding N...
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