Article
Okadaic acid induces transcription of junB through a CCAAT box and NF-Y.
Gene - 4 Apr 2001
Finch J S, Rosenberger S F, Martinez J D, Bowden G T
Abstract excerpt
The shellfish toxin, okadaic acid (OA), is a potent tumor promoter that induces expression of the proto-oncogene junB in mouse keratinocyte 308 cells. Here we show, through deletion analysis of the junB promoter, that sequences near the TATA box conferred transcriptional induction by OA. Transient transfections of luciferase constructs bearing the junB promoter with single mutations in various cis elements...
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