Article
Decrease in the insulin receptor protein level by anti-insulin receptor antibodies: roles of tyrosine kinase activity and receptor internalization.
Acta diabetologica - 1 Dec 2002
Fujita N, Yamasaki H, Yamakawa K, Uotani S, Kuwahara H, Degawa-Yamauchi M, Abe T, Ozaki M, Sera Y, Kawasaki E, Takino H, Yamaguchi Y, Eguchi K
Abstract excerpt
To investigate the mechanism of severe impairment of insulin action in type B insulin resistance, we extracted IgG from the serum of a patient with type B insulin resistance (B-IgG) and analyzed the inhibiting effect of B-IgG not only on insulin signaling but also on IGF-I signaling in Chinese hamster ovary (CHO) cells expressing human insulin receptor or human IGF-I receptor. Preincubation with 1 mg/ml B-IgG...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.