Article
Defects of insulin and IGF-1 action at receptor and postreceptor level in a patient with type A syndrome of insulin resistance.
Biochemical and biophysical research communications - 29 May 1997
Knebel B, Kellner S, Kotzka J, Siemeister G, Dreyer M, Streicher R, Schiller M, Rüdiger H W, Seemanova E, Krone W, Müller-Wieland D
Abstract excerpt
The action of insulin and IGF-1 in comparison to non-diabetic controls was studied in cultured fibroblasts of a patient with an inherited syndrome of insulin resistance (Type A syndrome). Insulin binding was reduced due to decreased receptor affinity, but sequence analyses revealed no alterations of splicing or primary insulin receptor (IR) structure. Most likely due to the IR affinity defect analyses of signal...
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