Article

Somatic Mutations in Familial Adenomatous Polyps

2003-09-01

Abstract excerpt

Germline mutations of the APC gene cause familial adenomatous polyposis coli (FAP). APC inactivation results in dysregulation of wnt/wingless signaling and contributes to chromosomal instability in vitro. To investigate somatic alterations that follow a known germline mutation and contribute to the transition from normal to neoplastic mucosa, we studied 10 adenomatous polyps from a 27-year-old patient with an APC...

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Literature Corpus work: 1fdb4ad0-d86d-564c-91da-be5e7434168b
DOI: 10.1309/4e4wg3aygjncd11p

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