Article
Mannose binding lectin (MBL) polymorphisms associated with low MBL production in patients with dermatomyositis.
The Journal of investigative dermatology - 1 Dec 2002
Werth Victoria P, Berlin Jesse A, Callen Jeffrey P, Mick Rosemarie, Sullivan Kathleen E
Abstract excerpt
One theory for the pathophysiology of photosensitive autoimmune skin diseases is that photoinduction of tumor necrosis factor alpha (TNFalpha) secretion leads to keratinocyte apoptosis and translocation of previously sequestered cellular antigens that then activate the immune system. We previously found an association of the overproducing TNFalpha-308 A variant with adult dermatomyositis and with subacute...
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