Article
Mannose-binding lectin promoter and structural gene variants in sarcoidosis.
European journal of clinical investigation - 1 Jun 2000
Foley P J, Mullighan C G, McGrath D S, Pantelidis P, Marshall S, Lympany P A, Welsh K I, du Bois R M
Abstract excerpt
BACKGROUND: Sarcoidosis is a chronic granulomatous disease of unknown aetiology. Studies have suggested that the causative agent may be an infectious micro-organism. The mannose binding lectin (MBL) is involved in innate immunity to a wide range of micro-organisms. Mutations in the promoter region and exon 1 of the MBL gene occur with high frequency and are associated with reduced serum levels of MBL and...
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