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Article

Mannose-binding lectin (MBL) codon 54 (rs1800450) polymorphism predisposes towards medium vessel vasculitis in patients with systemic lupus erythematosus.

Clinical rheumatology - 1 Apr 2017

Negi Vir Singh, Devaraju Panneer, Misra Durga Prasanna, Jain Vikramraj K, Usdadiya Jignesh Babulal, Antony Paul T, Gulati Reena

Abstract excerpt

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multiple etiological factors. Mannose-binding lectin (MBL) plays a key role in innate immunity by activating antibody-independent lectin complement pathway, opsonisation, phagocytosis, and immune complex (IC) clearance. Genetic polymorphisms in the promoter and coding regions of MBL gene affect the circulatory levels and biological activity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28097447
DOI: 10.1007/s10067-017-3539-3

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