Article
Association between early onset and organ manifestations of systemic lupus erythematosus (SLE) and a down-regulating promoter polymorphism in the MBL2 gene.
Clinical immunology (Orlando, Fla.) - 1 Dec 2007
Jakab L, Laki J, Sallai K, Temesszentandrási Gy, Pozsonyi T, Kalabay L, Varga L, Gombos T, Blaskó B, Bíró A, Madsen H O, Radics J, Gergely P, Füst G, Czirják L, Garred P, Fekete B
Abstract excerpt
The serum concentration of mannose-binding lectin (MBL) is genetically determined by a series of allelic polymorphisms in the MBL2 gene. Since several polymorphisms of the MBL2 gene have been suggested to be risk locus for systemic lupus erythematosus (SLE), we investigated MBL2 polymorphisms in 315 SLE patients from Hungary and 182 geographically matched healthy controls. Within the group of patients, we found...
Topics
- Adult
- Age Distribution
- Age of Onset
- Down-Regulation
- Female
- Genetic Predisposition to Disease
- Humans
- Lupus Erythematosus, Systemic
- Male
- Mannose-Binding Lectin