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Article

Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells.

Cell - 3 May 1996

Li L, Cohen S N

Abstract excerpt

Using a novel strategy that enables the isolation of previously unknown genes encoding selectable recessive phenotypes, we identified a gene (tsg101) whose homozygous functional disruption produces cell transformation. Antisense RNA from a transactivated promoter introduced randomly into transcribed genes throughout the genome of mouse 3T3 fibroblasts was used to knock out alleles of chromosomal genes adjacent to...

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Identifiers

PMID: 8616888
DOI: 10.1016/s0092-8674(00)81111-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells.PMID 8616888Read ↗

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TSG101 protein steady-state level is regulated posttranslationally by an evolutionarily conserved COOH-terminal sequence.Semantic proximity Read ↗

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