Article
Mammary gland neoplasia: insights from transgenic mouse models.
BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Jun 2000
Siegel P M, Hardy W R, Muller W J
Abstract excerpt
Current theories of breast cancer progression have been greatly influenced by the development and refinement of mouse transgenic and gene targeting technologies. Early transgenic mouse models confirmed the involvement of oncogenes, previously implicated in human breast cancer, by establishing a causal relationship between overexpression or activation of these genes and mammary tumorigenesis. More recently, the...
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