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Article

Compensation for dystrophin-deficiency: ADAM12 overexpression in skeletal muscle results in increased 7 integrin, utrophin and associated glycoproteins

5 Aug 2003

Abstract excerpt

Mouse models for genetic diseases are among the most powerful tools available for developing and testing new treatment strategies. ADAM12 is a disintegrin and metalloprotease, previously demonstrated to significantly alleviate the pathology of mdx mice, a model for Duchenne muscular dystrophy in humans. More specifically ADAM12 appeared to prevent muscle cell necrosis in the mdx mice as evidenced by morphological...

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PMID: 12915458
DOI: 10.1093/hmg/ddg264

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