Article
Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jan 2005
Kelly Kristine, Hutchinson Gillian, Nebenius-Oosthuizen Daniela, Smith Andrew J H, Bartsch Jörg W, Horiuchi Keisuke, Rittger Andrea, Manova Katia, Docherty Andy J P, Blobel Carl P
Abstract excerpt
ADAM8 (a disintegrin and metalloprotease 8, also referred to as MS2/CD156a) is a membrane-anchored metalloprotease that was first identified in a macrophage cell line and has been implicated in neurodegenerative diseases. Here, we evaluated the expression of ADAM8 during mouse development and generated mice lacking ADAM8 (Adam8-/- mice). During early mouse development, ADAM8 is expressed by maternal cells in the...
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