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Article

Deletion mutants of BMP folding variants act as BMP antagonists and are efficient inhibitors for heterotopic ossification.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 2003

Weber Franz E, Schmökel Hugo, Oelgeschläger Michael, Nickel Joachim, Maly Friedrich E, Hortschansky Peter, Grätz Klaus W

Abstract excerpt

UNLABELLED: Heterotopic ossification is a frequent complication in patients who have suffered head and neck traumas or have undergone total hip replacement. In this report, stable folding variants of the natural occurring osteoinductive BMPs were shown to act as inhibitors for heterotopic ossification. The most effective BMP folding variant construct performed even better than the natural occurring BMP antagonist...

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PMID: 14672349
DOI: 10.1359/jbmr.2003.18.12.2142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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