Article
Ribavirin causes error catastrophe during Hantaan virus replication.
Journal of virology - 1 Jan 2003
Severson William E, Schmaljohn Connie S, Javadian Ali, Jonsson Colleen B
Abstract excerpt
Except for ribavirin, no other antiviral drugs for treating hantaviral diseases have been identified. It is well established that ribavirin will inhibit the production of infectious Hantaan virus (HTNV); however, its mechanism of action is unknown. To characterize the inhibitory effect of ribavirin on HTNV, the levels of viral RNAs, proteins, and infectious particles were measured for 3 days posttreatment of...
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