Article
Error-prone replication of West Nile virus caused by ribavirin.
Antiviral research - 1 Jul 2005
Day Craig W, Smee Donald F, Julander Justin G, Yamshchikov Vladimir F, Sidwell Robert W, Morrey John D
Abstract excerpt
Ribavirin has been reported to cause error-prone replication and viral extinction in RNA viruses. The antiviral activity of ribavirin against West Nile virus (WNV) was evaluated in various cell lines to select a model in which mutagenic effects could be studied. The antiviral activity was greatest in HeLa cells as compared to CV-1, L929, Vero, or MA-104 cells. WNV was also passaged sequentially in cell monolayers...
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