Article
Association testing by DNA pooling: an effective initial screen.
Proceedings of the National Academy of Sciences of the United States of America - 24 Dec 2002
Bansal Aruna, van den Boom Dirk, Kammerer Stefan, Honisch Christiane, Adam Gail, Cantor Charles R, Kleyn Patrick, Braun Andi
Abstract excerpt
With an ever-increasing resource of validated single-nucleotide polymorphisms (SNPs), the limiting factors in genome-wide association analysis have become genotyping capacity and the availability of DNA. We provide a proof of concept of the use of pooled DNA as a means of efficiently screening SNPs and prioritizing them for further study. This approach reduces the final number of SNPs that undergo full,...
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